![]() To identify relevant articles, we systematically searched PubMed, Google Scholar and Cochrane Database of Systematic Review. We conducted a comprehensive review of literature describing perinatal SARS-CoV-2 infection which included articles published between November 2019 and June 2020. SARS-CoV-2 infection has also been reported in pregnant women and neonates, but the data is scattered and limited. Since the beginning of this epidemic, SARS-CoV-2 has now spread to all continents and was declared as pandemic by WHO on Ma( ). In early December 2019, an outbreak of respiratory illness of unknown origin was reported in Wuhan, Hubei Province, China, which was later isolated and reported as SARS-CoV-2 virus. The severe acute respiratory distress syndrome coronavirus (SARS-CoV), Middle East respiratory syndrome-related coronavirus (MERS CoV) and novel severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) belong to the genus Beta coronavirus. ![]() So far, seven human coronaviruses (HCoVs) have been identified, all of which fall within the Alpha and Beta coronavirus genera. The Coronaviridae family has Orthocoronavirinae subfamily which is further divided into four genera, namely, Alpha, Beta, Gamma, and Delta coronavirus. Respiratory distress is the most common manifestation.Ĭoronaviruses are positive sense single strand RNA viruses of zoonotic origin surrounded by an envelope. The COVID-19 seems to have favourable neonatal outcomes. Of the 35 positive neonates, 14 (40%) were symptomatic. ![]() Only 35 of the 629 tested neonates (5.5%) were positive for COVID-19. Respiratory support was needed in 60 neonates (7.6%), with 14 babies needing mechanical ventilation (1.8%), 25 needing non-invasive ventilation and 21 needing nasal oxygen. The commonest symptom in neonates was respiratory distress. Out of 793 neonates born, 629 neonates (79%) were tested after birth. There were 3 still births and 107 (14%) were delivered preterm. This review included 786 mothers, among which 64% (504) were delivered by caesarian section. We conducted a comprehensive search of PubMed, Google Scholar and Cochrane Database of Systematic Review between November 2019 and June 2020 and screened articles related to perinatal COVID-19. This review explores the clinical characteristics and outcomes of COVID-19 in neonates born to mothers who were detected with the virus during the pregnancy. In this review, we aim to summarize available literature on the clinical spectrum of COVID-19 in neonates and mothers and suggest a practical approach towards management of clinical scenarios. Most of the existing literature is in the form of case series or single-centre experience. The clinical spectrum of the perinatal COVID-19 and prospective data on neonatal outcomes remains largely unexplored.
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